The Institute for Quality and Efficiency in Health Care (IQWiG) confirms the efficacy of nicotine and varenicline in tobacco cessation.The assessment reveals that nicotine replacement therapy and varenicline are effective in helping individuals quit smoking.However, there are gaps in data regarding the efficacy of bupropion and cytisine for severe tobacco addiction.The findings highlight the importance of personalized medicine and the role of healthcare providers in assisting patients with smoking cessation.