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Linking Mutation Profiles from Next-Generation Sequencing to Histopathological Features in Lung Squamous Cell Carcinoma
- Lung Squamous Cell Carcinoma (LSCC) poses challenges in oncology as the second most common NSCLC type, lacking in molecular characterization and targeted therapies compared to LADC.
- Next-generation sequencing (NGS) studies shed light on LSCC mutation profiles, aiding personalized medicine by tailoring treatments to individual tumor profiles.
- NGS panels revealed 94 mutations across 23 genes in LSCC patients, with TP53, NF1, and PTEN being frequently mutated genes, offering insights into disrupted pathways.
- Notable findings include PIK3CA mutations correlating with younger patient age, PTEN mutations with inflammatory reactions, and NF1 mutations with pleural involvement.
- Molecular heterogeneity in LSCC influences tumor behavior and therapeutic strategies, prompting the need for precise treatment based on genomic signatures.
- Identification of novel mutations like NF1, PTEN, and PIK3CA presents opportunities for targeted therapies in LSCC by targeting RAS-MAPK and PI3K-AKT pathways.
- Individualized treatment plans are essential for LSCC due to diverse driver mutations, calling for biomarker-driven decision frameworks in clinical management.
- Integrating NGS panels into routine pathology workflows enhances actionable genetic alteration detection for targeted therapy trials and prognostic insights.
- Future therapeutic approaches for LSCC may involve combination regimens targeting multiple pathways, necessitating collaborative efforts in innovative drug development.
- This study underscores the significance of molecular diagnostics in lung cancer care, paving the way for personalized treatment strategies based on tumor genetic makeup.
- Advancements in NGS technologies and collaborative research hold promise for a transformative era in managing LSCC through tailored targeted therapies and molecular insights.
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