<ul data-eligibleForWebStory="true">The study focuses on unsupervised high-dimensional quantitative MRI reconstruction using a novel framework called LoREIN.Quantitative MRI plays a crucial role in clinical diagnosis by providing tissue-specific parameters.Current reconstruction methods struggle with highly undersampled data in multi-parametric qMRI.LoREIN integrates low-rank and continuity priors through LRR and INR to enhance reconstruction accuracy.The framework utilizes INR for spatial bases estimation and high-fidelity reconstruction of weighted images.Predicted multi-contrast weighted images improve reconstruction accuracy of quantitative parameter maps.LoREIN's approach includes zero-shot learning, which has potential in high-dimensional image reconstruction tasks.The study contributes to the field of medical imaging by advancing complex spatiotemporal reconstruction techniques.