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Low-temperature plasma halves cancer recurrence in mice
- Low-temperature plasma is being explored as a promising treatment for inhibiting tumour recurrence in cancer. Researchers at the University of Tokyo used streamer discharge to reduce melanoma tumour recurrence in mice post-surgery.
- The plasma treatment was found to significantly decrease the recurrence rate of melanoma tumours, highlighting its potential as an adjuvant therapy after surgical resection.
- Experiments showed that plasma treatment reduced tumour recurrence by approximately 50% without affecting the overall health of the animals.
- The cytotoxic effects of streamer discharge on cancer cells were confirmed, with a rapid transition from apoptosis to necrosis observed post-treatment.
- Streamer discharge generated reactive species that killed residual cancer cells at the resection site, potentially triggering immunogenic cell death.
- The unique therapeutic effect of streamer discharge, along with its low cost and ease of operation, make it a promising candidate for clinical application after tumour resection.
- The study suggests that streamer discharge may offer advantages over other cold atmospheric plasmas and warrants further investigation for future research and potential clinical use.
- Clinical applications of plasma treatment to reduce cancer recurrence risk are a long-term goal, following positive results in mice experiments.
- The study findings were published in the Journal of Physics D: Applied Physics, showcasing the potential of low-temperature plasma in cancer therapy.
- Research continues to explore the mechanisms by which plasma inhibits tumour recurrence, with a focus on its cytotoxic effects and potential for inducing immunogenic cell death.
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