This study aimed to develop a machine learning (ML) algorithm for determining cardiovascular risk in type 1 diabetes mellitus patients using multimodal retinal images.
Radiomic features from fundus retinography, optical coherence tomography (OCT), and OCT angiography (OCTA) images were extracted.
ML models trained with radiomic features achieved AUC values of 0.79 for identifying moderate risk cases from high and very high-risk cases, and 0.73 for distinguishing between high and very high-risk cases.
The addition of clinical variables improved AUC values, reaching 0.99 for identifying moderate risk cases and 0.95 for differentiating between high and very high-risk cases.