Traditional methods for malware detection are no longer sufficient in cybersecurity, leading to the adoption of machine learning-based approaches.The article focuses on using Machine Learning algorithms with the APIMDS dataset for malware detection.The dataset contains API call sequences of malware samples classified by Kaspersky AntiVirus.Each row in the dataset corresponds to a software sample, with API call sequences being the main components.The article discusses the challenges faced due to varying column lengths in the dataset when using Pandas for data processing.The manual operation involves organizing the data to represent API calls as columns with binary values for presence.The process includes cleaning the dataset, adjusting the malware_class column to differentiate between harmless and harmful software.After preparation, the dataset consists of 17268 rows and 1165 columns for machine learning analysis.Analysis reveals the most frequently used API calls in the dataset, showcasing critical calls for malware detection.The dataset is now clean and ready for model training using machine learning techniques for malware detection.