A naukri.com initiative
Bioengineer
7d
124
Image Credit: Bioengineer
Mapping Striatal Changes Linked to Parkinson’s Cognitive Decline
- A study published in npj Parkinsons Disease in 2025 delves into the striatum's functional gradients in Parkinson's patients with cognitive decline.
- The research reveals how changes in the striatum accompany continuous cognitive impairment in Parkinson's disease.
- The striatum's role in both motor control and cognitive functions makes it a key focus for understanding cognitive decline in Parkinson's.
- Advanced neuroimaging techniques were employed to map functional gradients in Parkinson's patients with varying cognitive impairments.
- Disrupted striatal gradients correlated with worsening cognitive deficits in Parkinson's, indicating altered connectivity patterns.
- The study links gene expression patterns in the striatum to changes in functional gradients, revealing pathways related to Parkinson's pathology.
- Notable genes involved in dopamine signaling and mitochondrial function showed differential expression along the altered striatal gradients.
- Identifying early biomarkers for cognitive impairment through gradient patterns and gene expression could revolutionize clinical diagnosis and interventions.
- This research emphasizes network dynamics over localized damage, offering insights into neurodegenerative cognitive deficits in Parkinson's disease.
- The study sets a precedent for holistic brain mapping in neurological diseases by integrating functional MRI and transcriptomic data.
Read Full Article
7 Likes
For uninterrupted reading, download the app