MIT researchers have introduced Boltz-1, an open-source model that achieves AlphaFold3-level accuracy in biomolecular structure prediction.Boltz-1 follows the framework of AlphaFold3 but introduces architectural and procedural innovations to enhance accuracy and accessibility.The model utilizes novel algorithms for sequence alignment and a unified cropping approach for efficient training.Boltz-1's breakthrough could accelerate discoveries in drug design, structural biology, and synthetic biology.