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MIT Researchers Propose Boltz-1: The First Open-Source AI Model Achieving AlphaFold3-Level Accuracy in Biomolecular Structure Prediction

  • MIT researchers have introduced Boltz-1, an open-source model that achieves AlphaFold3-level accuracy in biomolecular structure prediction.
  • Boltz-1 follows the framework of AlphaFold3 but introduces architectural and procedural innovations to enhance accuracy and accessibility.
  • The model utilizes novel algorithms for sequence alignment and a unified cropping approach for efficient training.
  • Boltz-1's breakthrough could accelerate discoveries in drug design, structural biology, and synthetic biology.

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