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MRD Assessment: Prospects and Pitfalls in Myeloma Care
- The landscape of multiple myeloma (MM) care has shifted with the rise of measurable residual disease (MRD) assessment, offering enhanced monitoring and treatment evaluation.
- MRD detection, utilizing advanced technologies like next-generation flow cytometry and sequencing, provides deep insights into tumor burden and treatment response.
- Achieving MRD negativity correlates strongly with improved progression-free survival (PFS) and overall survival (OS), impacting clinical decision-making and trial assessment.
- Standardization, assay variability, and data complexity pose challenges to widespread MRD implementation in clinical settings.
- Integrating MRD data with other prognostic markers is crucial to contextualize patient outcomes and tailor treatment strategies effectively.
- Regulatory recognition of MRD negativity as a valid endpoint expedites drug approvals and drives innovation in MM therapies.
- Personalized treatment approaches based on MRD status offer the potential for tailored interventions, balancing efficacy and toxicity for individual patients.
- The convergence of AI, mass spectrometry, and advanced imaging with MRD assessment enhances disease mapping and precision in monitoring disease progression.
- Adopting MRD-guided strategies requires multidisciplinary collaboration, provider education, and patient communication to optimize care outcomes.
- While MRD assessment holds great promise in MM management, addressing challenges in standardization, interpretation, and long-term validation is crucial for its successful integration into routine practice.
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