<ul><li>Protein function prediction has improved using high-precision protein structures predicted by AlphaFold2.</li><li>A new model called MSNGO integrates structural features and network propagation methods for multi-species protein function prediction.</li><li>Using structural features significantly enhances the accuracy of multi-species protein function prediction.</li><li>MSNGO outperforms previous methods relying on sequence features and protein-protein interaction networks.</li></ul>

MSNGO: multi-species protein function annotation based on 3D protein structure and network propagation

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