<ul><li>Protein structure prediction models can now generate accurate 3D structural hypotheses from sequence alone.</li><li>Cryo-electron microscopy (cryo-EM) has become a powerful tool for imaging near-native structural heterogeneity.</li><li>A new method, CryoBoltz, combines cryo-EM density maps with sequence and biophysical priors to guide protein structure prediction models, allowing accurate prediction of dynamic biomolecular complexes.</li><li>CryoBoltz demonstrates the ability to build atomic models into heterogeneous cryo-EM maps for various biomolecular systems like transporters and antibodies.</li></ul>

Multiscale guidance of AlphaFold3 with heterogeneous cryo-EM data

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