NASA astronauts Anne McClain and Nichole Ayers will answer science, technology, engineering, and mathematics-related questions from Richmond Hill, New York.
The 20-minute space-to-Earth call will be broadcast on NASA+ at 12 p.m. EDT on March 26.
The event aims to inspire Richmond Hill High School students to pursue STEM careers.
As part of NASA's Artemis campaign, astronauts will be sent to the Moon to prepare for future Mars exploration.