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Neutrophil-Lymphocyte Ratio Tracks Glioblastoma Recurrence
- A recent study published in BMC Cancer explores the use of neutrophil-to-lymphocyte ratio (NLR) dynamics as a prognostic tool for glioblastoma (GBM) recurrence.
- GBM is a challenging brain tumor with high recurrence rates, prompting the search for reliable biomarkers to predict outcomes and monitor disease progression.
- Elevated NLR values, indicating systemic inflammation, have been linked to tumor progression in various cancers, including GBM.
- The study analyzed NLR changes in 69 GBM patients undergoing the Stupp protocol, revealing associations between post-treatment NLR and overall survival.
- Patients with high post-Stupp NLR or dynamic NLR increases had significantly poorer survival outcomes, independent of other clinical factors.
- NLR dynamics also correlated with progression-free survival, suggesting its potential as a surveillance biomarker for early GBM recurrence detection.
- The interaction between neutrophils and lymphocytes in the tumor microenvironment plays a crucial role in GBM progression and immune response.
- Changes in NLR during treatment reflect evolving immune profiles and may signal treatment response or resistance development in GBM patients.
- Despite the study's limitations, the findings highlight the potential of NLR dynamics to guide personalized treatment strategies in GBM.
- Integrating NLR monitoring into clinical practice could enhance the precision of prognosis and treatment adjustments for GBM patients.
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