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New Insights into Adipocyte-Hepatocyte Communication Revealed During Endoplasmic Reticulum Stress Response
- The endoplasmic reticulum (ER) plays a crucial role in cellular protein synthesis, folding, and quality control, and ER stress can lead to cellular responses like the unfolded protein response (UPR). Prolonged ER stress can result in maladaptive responses and cell death, posing concerns in metabolic diseases.
- Research by Professor WANG Likun's team reveals intercellular signaling between ER-stressed adipocytes and hepatocytes through ceramide, a key signaling molecule impacting stress responses and cell survival.
- Ceramide secretion in response to ER stress in adipocytes activates UPR in neighboring hepatocytes, showing how adipose tissue can influence liver function and organ crosstalk in human physiology.
- Lipidomics analysis identified ceramide release from adipocytes due to ER stress mediated by acid sphingomyelinase, showcasing indirect communication between adipocytes and hepatocytes.
- Transportation of ceramide between cells involves high-density lipoprotein (HDL), impacting membrane fluidity and UPR activation in hepatocytes, suggesting new therapeutic strategies for metabolic disorders tied to ER stress.
- Research indicates that altering ceramide levels can reverse membrane fluidity changes through sphingomyelin supplementation, highlighting the potential for restoring lipid metabolism balance to manage cellular stress.
- Insights from this study provide a framework for understanding tissue coordination in stress responses and metabolic disorders, emphasizing the impact of lipid metabolism disruptions on overall health outcomes.
- Interventions targeting ceramide synthesis and transport pathways offer new possibilities for treating metabolic diseases resulting from chronic ER stress, potentially revolutionizing current treatment approaches.
- This research broadens understanding of cellular communication under ER stress, paving the way for innovative therapeutic strategies targeting lipid metabolism in metabolic disorders to improve health outcomes.
- By exploring intercellular signaling through ceramide, this study opens avenues for developing treatments that address cellular communication failures underlying metabolic diseases, offering a promising approach to disease management.
- Professor WANG Likun's research contributes significantly to comprehending ceramide's role in mediating signals between adipocytes and hepatocytes, advancing knowledge in cellular communication, ER stress, and metabolic health.
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