A naukri.com initiative
Bioengineer
5d
253
Image Credit: Bioengineer
New Study Uncovers Genetic Complexity Behind Cancer Metastasis
- A recent groundbreaking study conducted by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center has provided new insights into the genomic evolution of cancer during metastasis.
- The research, led by experts like Dr. Luc Morris and Dr. Xi Kathy Zhou, analyzed genomic data from over 3,700 patients with 24 different cancer types to understand the genetic changes in metastatic tumors.
- Metastatic tumors were found to have a higher burden of copy-number alterations (CNAs) compared to point mutations, indicating the role of chromosomal rearrangements in genomic instability during metastasis.
- One significant finding was the prevalence of whole-genome doubling (WGD) in metastatic cancer cells, which provides genetic redundancy and enhances adaptability and survival.
- The study highlighted the importance of genomic instability, particularly CNAs, in enabling metastatic tumors to evade immune surveillance and resist immunotherapy treatments.
- The evolutionary trajectory of metastatic cancer favors genetic changes that maximize genomic instability while minimizing mutations that may trigger an immune response.
- The distinct genomic profile of metastatic tumors calls for refined biomarkers to guide treatment strategies, emphasizing the potential for targeting vulnerabilities created by CNAs and WGD in therapeutic interventions.
- Understanding the genomic landscape of metastases can lead to personalized treatment approaches and the development of novel agents to combat treatment-resistant phenotypes in advanced cancer.
- The study sheds light on the orchestrated evolutionary process of cancer metastasis, emphasizing the importance of chromosomal-scale changes in tumor behavior and patient outcomes.
- By integrating sequencing technologies into clinical practice and fostering collaborations between researchers and clinicians, advancements in cancer genomics can drive innovative treatment strategies for metastatic disease.
Read Full Article
15 Likes
For uninterrupted reading, download the app