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Paper-Based Devices Detect Malaria in Asymptomatic Individuals
- Scientists develop a paper-based device for detecting malaria in asymptomatic carriers, addressing challenges in remote regions.
- The device uses microfluidic technology and mass spectrometry for sensitive and portable on-site testing, showcasing superior performance over traditional methods.
- Field studies in Ghana demonstrate the device's high sensitivity of 96.5% in detecting malaria antigens, surpassing microscopy and rapid tests.
- The device's innovative design prevents blood leakage, ensures reagent stability, and offers near-perfect specificity with minimal false positives.
- It has potential for detecting other diseases by adapting antibody probes, showcasing versatility, low costs, and ease of production.
- Discussions with Ghana's government and ongoing research aim to integrate the device into national malaria control strategies and expand diagnostic capabilities.
- The breakthrough combines microfluidics, immunochemistry, and mass spectrometry, revolutionizing point-of-care testing and global health impact.
- The study was published in Analytical Chemistry and conducted by The Ohio State University researchers, supported by the National Institute of Allergy and Infectious Diseases.
- Key words: malaria detection, microfluidic paper device, mass spectrometry, asymptomatic infection, point-of-care testing, sub-Saharan Africa, portable diagnostics.
- Tags: disease diagnostics, engineered paper device, field testing, innovative healthcare solutions, malaria surveillance, rapid testing methods, sub-Saharan Africa malaria control.
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