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PD-1 Antibody Plus Chemo Boosts Gastric Cancer Treatment
- The ROSETTE trial investigates combining PD-1 antibody immunotherapy with chemotherapy and surgery for limited metastatic gastric cancer.
- Limited metastatic gastric cancer presents challenges as standard treatments may not be optimal for this specific population.
- The trial aims to improve survival outcomes by downstaging tumors and enhancing resectability through a systemic and surgical approach.
- It includes a multi-modality local treatment plan, addressing tumor heterogeneity and micrometastases that impact therapeutic success.
- Clinical endpoints like event-free survival, response rates, overall survival, and R0 resection rates are under rigorous evaluation.
- The trial's randomized design minimizes bias and advances the integration of surgery in metastatic gastric cancer treatment.
- Combining PD-1 inhibitors with chemotherapy may enhance immune responses and target gastric cancer's heterogeneity.
- Challenges include managing post-systemic treatment surgery risks and patient recruitment in defined subsets.
- Success in the trial could reshape treatment paradigms for limited metastatic gastric cancer, emphasizing multidisciplinary approaches.
- The study may pave the way for future research on oligometastatic cancers and offer insights for extending multimodal therapies across cancer types.
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