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Radioactive gold nanoparticles could track drug distribution in the body
- A new imaging technique using neutron-activated gold nanoparticles enables real-time visualization of drug distribution in the body without external tracers.
- Gold nanoparticles are attractive for targeted drug delivery in cancer treatment and can accumulate in tumors.
- Researchers in Japan are utilizing radioactive gold isotopes to image nanoparticle distribution in vivo.
- The radioisotope 198Au emits 412 keV gamma rays, facilitating activation imaging for tracking nanoparticle movement.
- Experiments involved injecting 198Au-based nanoparticles into mice tumors and using a hybrid Compton camera for imaging.
- The images showed nanoparticle accumulation in both the tumor and liver regions of the mice.
- The technique was also used to label astatine-211 for tracking drug distribution in tumor-bearing mice.
- The study demonstrated the potential for imaging drug distribution in real-time using activation imaging with gold nanoparticles.
- The researchers aim to expand the application of activation imaging to other nanoparticles and develop detectors for higher resolution imaging.
- This research, aiming for future clinical use, was published in Applied Physics Letters.
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