<ul data-eligibleForWebStory="true"><li>Cryo-electron microscopy (cryo-EM) is used in molecular biology to visualize 3D molecular structures from noisy 2D electron microscope images.</li><li>A novel 3D reconstruction framework named CryoSPIRE, inspired by Gaussian Splatting for 4D scene reconstruction, has been introduced for handling non-rigid conformational flexibility and compositional variations in imaged particles.</li><li>CryoSPIRE utilizes a hierarchical Gaussian mixture model to infer a part-based segmentation of particles, which helps in dealing with conformational and compositional variability.</li><li>The framework has shown the capability to reveal biologically significant structures in complex experimental datasets and has set a new benchmark on CryoBench, a cryo-EM heterogeneity methods benchmark.</li></ul>

Reconstructing Heterogeneous Biomolecules via Hierarchical Gaussian Mixtures and Part Discovery

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