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Researchers at Stanford Use AI and Spatial Transcriptomics to Discover What Makes Some Cells Age Faster/Slower in the Brain

  • Stanford and UCLA researchers created a spatially resolved single-cell transcriptomics atlas of 4.2 million mouse brain cells across 20 age points to understand brain aging.
  • T cells have a pro-aging effect on nearby cells, while neural stem cells exert a rejuvenating influence, according to the findings.
  • The study developed spatial aging clocks to identify cell-type-specific changes associated with aging, rejuvenation, and disease.
  • Targeting specific cell types in the brain could potentially combat tissue aging and promote rejuvenation.

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