Stanford and UCLA researchers created a spatially resolved single-cell transcriptomics atlas of 4.2 million mouse brain cells across 20 age points to understand brain aging.
T cells have a pro-aging effect on nearby cells, while neural stem cells exert a rejuvenating influence, according to the findings.
The study developed spatial aging clocks to identify cell-type-specific changes associated with aging, rejuvenation, and disease.
Targeting specific cell types in the brain could potentially combat tissue aging and promote rejuvenation.