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Retromer Complex Identified as a New Key Regulator of Melanoma Metastasis
- A study in Science China Life Sciences uncovers the role of the VPS35/Retromer complex in regulating MT1-MMP for cancer metastasis.
- MT1-MMP is crucial for cancer cells to invade tissues by remodeling the extracellular matrix.
- VPS35 interacts with MT1-MMP, protecting it from degradation and maintaining stability on cancer cell surfaces.
- Depletion of VPS35 leads to reduced MT1-MMP levels and diminished metastatic spread in melanoma models.
- VPS35 also influences transcriptional regulation of MT1-MMP via the STAT3 signaling pathway.
- Clinical data shows a correlation between VPS35 and MT1-MMP expression levels in melanoma patients with poor prognoses.
- Therapeutic strategies targeting VPS35 could disrupt MT1-MMP availability and inhibit cancer cell invasiveness.
- The study used various techniques to solidify findings, shedding light on the complex interplay between VPS35, MT1-MMP, and STAT3.
- Inhibiting VPS35 function or its interactions offers a potential anti-metastatic therapeutic approach.
- The research deepens understanding of metastatic mechanisms and may lead to innovative therapies grounded in cell biology.
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