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RhoFold+: A Deep Learning Framework for Accurate RNA 3D Structure Prediction from Sequences

  • RhoFold+ is an advanced deep learning framework for accurate RNA 3D structure prediction from sequences.
  • It leverages an RNA language model pretrained on over 23.7 million sequences and incorporates multiple sequence alignments (MSAs) to address data limitations.
  • RhoFold+ integrates a structure prediction module that employs a geometry-aware attention mechanism (IPA) for 3D structure refinement.
  • The model outperforms existing methods in accuracy and demonstrates faster prediction times, with high accuracy across multiple validation scenarios.

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