RhoFold+ is an advanced deep learning framework for accurate RNA 3D structure prediction from sequences.
It leverages an RNA language model pretrained on over 23.7 million sequences and incorporates multiple sequence alignments (MSAs) to address data limitations.
RhoFold+ integrates a structure prediction module that employs a geometry-aware attention mechanism (IPA) for 3D structure refinement.
The model outperforms existing methods in accuracy and demonstrates faster prediction times, with high accuracy across multiple validation scenarios.