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Rice chemists navigate terpenoid diversity through enzyme-driven scaffold hopping
- Rice University scientists introduce enzyme-driven strategy for diverse terpenoid scaffold transformations, challenging traditional synthetic approaches.
- Historically, terpenoid synthesis required unique blueprints for each scaffold, hindering efficiency and scalability.
- Renata's team utilizes enzymatic oxidation of sclareolide precursor to create varied terpenoids, revolutionizing synthetic paths.
- Novel technique combines enzymatic oxidation with abiotic scaffold hopping, enabling rapid terpenoid diversification.
- Four distinct terpenoid products synthesized from sclareolide showcase the method's efficiency and versatility.
- Enzymatic step acts as a shared entry point, reducing multi-step syntheses and material costs in natural product synthesis.
- Engineered cytochrome enzymes demonstrate remarkable selectivity, broadening their reactivity through protein engineering.
- Blend of enzymatic catalysis and chemical reactions unlocks new synthetic routes, enhancing biocatalysis in modern chemistry.
- Method not only aids in chemical synthesis but also holds promise for medicinal chemistry and sustainable drug discovery.
- Research signifies a shift in synthetic thinking, nurturing interdisciplinary collaborations for innovative chemical exploration.
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