Extravehicular Activity (EVA) architecture protocols for human exploration missions may lead to compromised health and performance due to exposure to mild hypobaric hypoxia.
Concerns include potential effects on intracranial pressure, visual impairment, cognitive performance, sensorimotor dysfunction, oxidative damage, and sleep quality.
Additional factors contributing to hypoxic exposure include cabin depressurization, system failures, toxic exposure, and crewmember illness/injury.
NASA is researching the risks of reduced crew health and performance due to hypoxia in order to develop effective countermeasures.