<ul data-eligibleForWebStory="true">Study shows B-cell developmental stage impacts pediatric B-ALL treatment outcomes.Research explores cellular origins of leukemia, aiding risk stratification and therapy targeting.Insights reveal diverse leukemia developmental paths challenging existing concepts on treatment resistance.Identification of multipotent leukemic cells suggests potential treatment evasion mechanism.Novel multipotency score predicts patient response, paving the way for personalized therapies.