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Terasaki Institute Creates 3D Microphysiological Model Unveiling Pericyte-Driven Chemoresistance in Glioblastoma
- Terasaki Institute scientists developed a 3D model replicating chemoresistance in glioblastoma by including pericytes, a critical component of the tumor microenvironment.
- The model integrates human GBM tumor cells with pericytes in a biomaterial scaffold mimicking brain tissue properties, enhancing drug response studies.
- Pericyte presence led to increased temozolomide (TMZ) resistance in GBM cell lines, linked to elevated CCL5 levels, a potential therapeutic target for overcoming chemoresistance.
- By emulating tissue-level properties accurately, the 3D model enables in-depth analysis of tumor-stroma interactions crucial for drug resistance mechanisms.
- The model supports precision medicine by assessing individual tumor responses and facilitating high-throughput drug screening in a tumor-like environment.
- This innovative platform offers a cost-effective, scalable alternative to animal models, aiding in oncology drug development and screening programs.
- The biomaterial scaffold's design mimics key physical properties influencing tumor behavior, enhancing the model's ability to replicate the brain tissue's constraints.
- Pericytes play a significant role in creating a protective niche for GBM cells, reducing TMZ efficacy, highlighting a potential avenue for therapeutic intervention.
- The study's publication in Acta Biomaterialia marks a landmark achievement at the intersection of tissue engineering, cancer biology, and translational medicine.
- The model developed by Terasaki Institute scientists holds promise in reshaping preclinical research by elucidating tumor microenvironment dynamics in drug resistance modulation.
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