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The Crucial Decade That Ion Channels Were Proven to Exist
- The article discusses the crucial decade during which ion channels were proven to exist by Bertil Hille and Clay Armstrong.
- Hodgkin and Huxley's research on a nerve axon in the 1950s did not mention ion channels, although they studied ion currents and conductance.
- Bertil Hille and Clay Armstrong played key roles in establishing the existence of ion channels from 1965 to 1975.
- Selective channels for different ions were supported by experiments using blocking chemicals like tetrodotoxin and tetraethylammonium.
- Hille's studies revealed the selectivity and size of ion pores, showing how ions interact with pore walls for permeation.
- Armstrong's experiments with TEA+ derivatives on the outward K+ current reinforced the idea of protein component in membrane pores.
- Initial resistance to the concept of ion channels was demonstrated at the 1966 Biophysical Society meeting.
- Clay Armstrong emphasized the importance of ion channels, stating them as a crucial class of proteins in the human body.
- The article provides a historical and qualitative review of how the existence of ion channels was demonstrated.
- Ion channels are highlighted as essential proteins in the human body, as expressed by Clay Armstrong, acknowledging their significance.
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