Large offsets in MySQL queries using LIMIT can significantly slow down performance, especially in deep pagination scenarios.The slowdown is due to MySQL processing all offset + count rows before discarding offset rows and returning requested rows.Factors like indexing, bookmark lookups, and filesorts contribute to the performance issues.To optimize, keyset pagination using starting values or covering indexes with subqueries are recommended.Keyset pagination allows direct seeking to the starting point, enhancing efficiency in sequential pagination.Covering indexes with subqueries reduce bookmark lookups, improving performance for arbitrary page jumps.Implementing covering indexes ensures all query requirements are met directly from the index, reducing costly lookups.Tools like Chat2DB provide AI-powered query optimization and EXPLAIN analysis to streamline SQL optimization processes.Chat2DB enhances productivity by assisting in complex query writing and database management tasks.