Thalamo-cortical loops are bidirectional circuits linking the thalamus and cerebral cortex, synchronizing perception and attention.Integrated Information Theory (IIT) quantifies consciousness with Φ, measuring the system's causal power exceeding that of its parts.Differentiation and integration in neural assemblies and thalamo-cortical loops manifest unified phenomenal states.Empirical examples show how differentiation and integration yield emergent collective awareness, emphasizing ethical and design imperatives.