A naukri.com initiative
Bioengineer
2w
151
Image Credit: Bioengineer
Unraveling Cancer Immunotherapy: The Mechanisms Behind Therapeutic Antibodies
- Researchers at University of Würzburg in Bavaria, Germany have made a major breakthrough in therapeutic antibodies.
- A new super-resolution microscopy technique known as LLS-TDI-DNA-PAINT is allowing for real-time observation of how therapeutic antibodies bind to target proteins on cancer cells in unprecedented detail and accuracy.
- Therapeutic antibodies are a crucial approach in treating tumors such as chronic lymphocytic leukaemia.
- The study revealed the intricate interactions between antibodies and target molecules, especially B-cells.
- The novelty of the study is that it showcases the inner workings of therapeutic antibody-b-cell interactions.
- Use of the LLS-TDI-DNA-PAINT cryotechnology reveals how therapeutic antibodies not only adhere to CD20 molecules but affect B-cells' structural behavior as well.
- Results reveal that the architecture of cell membranes plays a significant role in immune responses.
- Further exploration into hedgehog-shaped B-cells is causing researchers to delve deeper into the broader immune system response.
- Use of the LLS-TDI-DNA-PAINT method allows us to uncover the molecular interplays of CD20 and therapeutic antibodies at a novel scale.
- The study holds the promise that therapeutic antibodies can be tailored based on direct observations of their interactions in the tumor microenvironment.
Read Full Article
9 Likes
For uninterrupted reading, download the app