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Very high-energy electrons could prove optimal for FLASH radiotherapy

  • Electron therapy has long been important in cancer treatments, with energies up to 20 MeV ideal for certain applications.
  • Very high-energy electrons (VHEEs) with energies up to 400 MeV could revolutionize radiation treatments.
  • THERYQ aims to make VHEE-based treatments a reality by adapting CERN technology for clinical use.
  • VHEEs offer deep penetration, narrow beam edges, and robustness against tissue density variations.
  • Electromagnetic scanning allows precise manipulation of VHEE beams with smaller footprint and cost.
  • VHEE beams enable FLASH radiotherapy, delivering ultrahigh dose rates while reducing normal tissue toxicity.
  • Clinical trials with FLASH radiotherapy show promise, with initial focus on skin lesions progressing to deeper tumors.
  • VHEEs could be particularly beneficial for radioresistant cancers, sparing normal tissue while increasing target doses.
  • Technological challenges remain, but the goal is to make VHEE accelerators compact and practical for clinical use.
  • The potential of VHEEs for FLASH radiotherapy brings hope for improved cancer treatments in the future.

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