The Weak-to-Strong Diffusion (W2SD) framework is proposed to reduce the gap between generated outputs and real data in diffusion generative models.W2SD utilizes the estimated difference between weak and strong models to bridge the gap and align latent variables with the real data distribution.The W2SD framework is highly flexible and applicable to various model pairs and modalities, achieving state-of-the-art performance.Experiments demonstrate significant improvements in human preference, aesthetic quality, and prompt adherence with W2SD.