A/B testing assumes isolated treatments and neat conclusions but real systems are unpredictable and complex.
In cases where fraud prevention or security are involved, A/B testing may not be reliable due to adaptability and response from adversaries.
In scenarios with ethical or high financial consequences, responsible product leaders rely on expert judgment and careful rollout strategies instead of A/B testing.
Low-frequency domains and small sample sizes pose challenges for A/B testing, leading to inconclusive results. Alternative methods like offline evaluation and simulation are preferred in such cases.