A naukri.com initiative
Bioengineer
13h
61
Image Credit: Bioengineer
When Diet Turns Deadly: The Hidden Bug Affecting Cancer Therapy
- A study by Ludwig Cancer Research reveals the impact of diet and gut microbiome on cancer therapy efficacy, particularly with PI3 kinase inhibitors.
- Research found unexpected interactions between specific diets and drug responsiveness, challenging conventional assumptions in oncology and nutrition science.
- The study highlighted that the molecular complexity of the diet, rather than macronutrient composition or insulin dynamics, influenced drug efficacy.
- Commensal gut bacteria metabolizing phytochemicals into bioactive compounds induced hepatic enzymes that metabolize cancer drugs, affecting drug clearance and efficacy.
- Experimental evidence in mice demonstrated the impact of diet on drug metabolism and treatment outcomes, emphasizing the role of the gut microbiome.
- The findings suggest that diet-microbiome interactions could widely influence cancer therapeutics and drug metabolism across various diseases.
- The research advocates for the integration of dietary considerations and microbiome profiling in clinical trials and personalized treatment strategies.
- This study opens avenues for tailored cancer therapy based on individual dietary habits and gut microbial composition, potentially optimizing treatment effectiveness.
- The importance of considering a patient's diet and microbiome in shaping drug pharmacokinetics and therapeutic outcomes is highlighted, with the potential for improving cancer treatment precision.
- Funding for the study was provided by the Ludwig Institute for Cancer Research, Stand Up 2 Cancer, the U.S. National Institutes of Health, and the New Jersey Commission on Cancer Research.
Read Full Article
3 Likes
For uninterrupted reading, download the app