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Wireless deep brain stimulation reverses Parkinson’s disease in mice
- A nanoparticle-based deep brain stimulation system has successfully reversed Parkinson’s disease symptoms in mice by boosting dopamine levels and clearing out harmful fibrils.
- Current DBS treatments aim to amplify dopamine signaling, but do not stop disease progression by restoring degenerated neurons.
- Researchers developed a photothermal, wireless DBS system using TRPV1 activation and β-syn peptides to clear α-syn fibrils in the brain.
- The DBS nanoparticles anchor to dopamine neurons, convert NIR irradiation into heat, activate TRPV1 receptors, and trigger autophagy.
- In vitro tests showed the nanoparticles reduced neuron death induced by α-syn preformed fibrils.
- In vivo studies in mice with Parkinson's disease demonstrated improved motor abilities and restored dopamine neurons after DBS treatment.
- Motor tests showed treated mice outperformed untreated ones and had near comparable performance to healthy mice.
- The nanoparticles remained stable in the brain with no considerable toxicity observed after treatment.
- Future research aims to further explore gold clusters' neuroprotective properties for potential multifunctional therapeutic strategies.
- The study was reported in Science Advances and offers promising insights into innovative treatments for Parkinson’s disease.
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